It's out, bro. Monkey's out of the bottle, old man.
5 seconds sound clip from the Pineapple Express movie soundboard.
You can hear this line at 01:16:18 in the Blu-ray version of the movie.
Quote context
[...]
- How about in the park when I said that you were my friend? You didn't say anything back.
- Well, that's easy. It's 'cause we're not friends.
- You are my drug dealer. There's one reason we know each other. I like the drugs you sell. That's it.
- That sounded mean. Just hearing it sounded mean. I didn't mean to say all that, man.
- It's out, bro. Monkey's out of the bottle, old man.
- What? That's not even an expression.
- Pandora doesn't go back in the box. He only comes out.
- I'm sorry, man. Look... What are you doing?
- Here. Have a nice last meal.
[...]