No, there's no way that's correct.
4 seconds sound clip from the Anchorman: The Legend of Ron Burgundy movie soundboard.
You can hear this line at 00:30:36 in the Blu-ray version of the movie.
Quote context
[...]
- San Diego. Drink it in, it always goes down smooth.
- It's a fact, it's the greatest city in the history of mankind.
- No, there's no way that's correct.
- I'm sorry, I was trying to impress you.
- I'll be honest, I don't think anyone knows what it means anymore.
- Scholars maintain that the translation was lost hundreds of years ago.
- Doesn't it mean Saint Diego?
[...]