You are not a man. You are a big, fat joke.
4 seconds sound clip from the Anchorman: The Legend of Ron Burgundy movie soundboard.
You can hear this line at 01:07:31 in the Blu-ray version of the movie.
Quote context
[...]
- I'm a professional and I would like to be able to do my job.
- Well, big deal. I am very professional.
- I'm not a baby, I'm a man. I am an anchorman.
- You are not a man. You are a big, fat joke.
- You're just a woman with a small brain. With a brain a third the size of us. It's science.
- You are a smelly pirate hooker.
[...]