They're like left-handed pitchers. They all have a screw loose somewhere.
5 seconds sound clip from the The Asphalt Jungle (1950) movie soundboard.
You can hear this line at 00:39:19 in the Blu-ray version of the movie.
Quote context
[...]
- That busted-down wrestler? Are you kidding? He's got nothing upstairs but solid knuckle.
- I'm a stranger and do not know as much as you gentlemen.
- But what about this Southerner, this Dix?
- He impressed me as a very determined man and far from stupid.
- Frankly, I don't like the guy, but I never saw a hooligan I did like.
- They're like left-handed pitchers. They all have a screw loose somewhere.
- I suppose he's as good as anybody though.
- Gus thinks he's tops, and Gus is usually right.
- I like him. I say we take him.
- Well, I better be getting home now. Mrs. Ciavelli's worried about the kid.
[...]